Ovarian mesenchymal stem cells
Grant Project Details:
Young women who undergo chemotherapy for cancer may face infertility. Our experiments are designed to learn how chemotherapy affects the ovaries. We propose to characterize murine ovarian mesenchymal stem cells and identify sub‐populations with enhanced differentiation capacity inside (multipotent) and outside (pluripotent) of the mesoderm. We would like to define these cells using single cell sequencing and characterize their regenerative capacity using a murine model of chemotherapy‐induced of ovarian dysfunction.