Brain irradiation is the standard of treatment for most brain tumors. Irradiating the brain prolongs patient survival, but often results in long term memory and functional impairments. These deficits are driven by radiation injury to myelinating cells, oligodendrocytes. One method to prevent deficits is to replace myelin by transplanting in new stem cells to the brain. We will test the safety and effectiveness of human glial cells to protect the brain in a model of radiation‐induced brain injury during therapy for brain cancer.
Our goal is to engineer a humanized swine model that carries key human cytokines, this strategy will provide the immunology field a high capacity and robust platform that promotes hematopoietic stem cells, CAR T cells, innate immune cells production, differentiated and cultured in high volume bioincubators. Humanized MISTRG porcine model could also become the new gold standard of immune response therapies before the final step of stage four of drug testing for human applications, altering the mouse as the commonly used model.