Augmenting Liver Regeneration at the Single Cell Level
Grant Project Details:
Rory Smoot, MD
Mayo Clinic | Rochester, MN
This application examines the mechanisms by which targeting the molecule YAP with medications can facilitate liver regeneration. We propose that YAP is functioning in multiple cell types within the liver and that the mechanisms differ between the cell types. The results of these studies have the potential to identify new optimization strategies for using these medications, and to identify new therapeutic targets to further augment liver regeneration.