Clinical Trials

Clinical trials seek to translate regenerative medicine research into clinical therapies. Learn more about how to apply for a grant by reading our frequently asked questions. 

 

See where clinical trials have taken place across Minnesota.
Michael Barry, PhD
Phase 1 Study of Intravenous Administration of Adeno-Associated Virus Gene Therapy for Individuals with Propionic Acidemia
Propionic acidemia (PA) is a severe metabolic disorder caused by mutations in the PCCA gene. Traditional treatments, including stringent life-long…
2024-2028
image of Atta Behfar, MD, PhD
Atta Behfar, MD, PhD
Safety Evaluation of Intracoronary infusion of extracellular vesicles in patients with AMI (EV‐AMI)
This research tests a new product for patients who have had a heart attack (AMI, acute myeocardial infarction). This product would help protect and…
2020-2022
image of LaTonya Hickson, MD
LaTonya Hickson, MD
Patient-derived Mesenchymal Stromal Cell Therapy in Diabetic Kidney Disease: A Phase I Study
Diabetic kidney disease (DKD) is the most common cause of kidney failure in the U.S. and has no adequate cure. Mesenchymal stromal cell (MSC)…
2019-2021
image of Mohamad Bydon, MD
Mohamad Bydon, MD
CELLTOP: A Phase I Clinical Trial of Autologous Adipose Derived Mesenchymal Stem Cells in the Treatment of Paralysis due to Traumatic Spinal Cord Injury
This clinical trial investigates whether adipose-derived (fat tissue-derived) mesenchymal stem cells can be safely administered into the…
2018-2020
image of Aaron Krych, MD
Aaron Krych, MD
The RECLAIM trial for focal cartilage repair
The goals of this project are to test the initial safety and feasibility of RECLAIM, a single stage cartilage repair technique using the patient’s…
2018-2020
image of Rodrigo Ruano, MD, PhD
Rodrigo Ruano, MD, PhD
Fetoscopic regenerative therapy for severe pulmonary hypoplasia - a feasibility pre-randomized controlled trial study
When a baby’s lungs are not adequately developed at birth, severe complications and even death can result. Dr. Ruano brings expertise in a…
2017-2019
image of Shernan Holtan, MD
Shernan G. Holtan, MD
Phase I/II study of human chorionic gonadotropin and epidermal growth factor supplementation (Pregnyl) to support tolerance and repair as adjunct therapy in high-risk or refractory acute graft-versus-host disease
Interim report: Patient enrollment continues. Additionally, correlative studies have provided important data on regulatory T cell responses and…
2017-2019
image of Nathan P. Staff, MD, PhD
Nathan P. Staff, MD, PhD
A Phase IIA study using intrathecal treatment of autologous adipose-derived mesenchymal stem cells for amyotrophic lateral sclerosis
The overall objective of this proposal is to conduct a multi-site, placebo-controlled Phase IIA clinical trial to obtain clinical data on the…
2016-2018
image of Kimberly Holst, MD
Kimberly Holst, MD
Phase I study of delivery of autologous bone marrow derived mononuclear cells to myopathic right ventricle in patients with Ebstein anomaly during surgical intervention
The goal of this Phase I study is to establish the safety and feasibility of intramyocardial injection of autologous bone marrow derived…
2016-2018