Research Grants Awarded

Reseach grants support Minnesota scientific and medical research that has the potential to translate to clinical advances in regenerative medicine. Grants typically open every September. Learn more about how to apply for a grant by reading our frequently asked questions. 

 

View research grants awarded by year.
Melanie Graham, MPH, PhD and Quinn P. Peterson, PhD
Harnessing the Regenerative Microenvironment of the Liver Surface: A Perihepatic Niche for Stem Cell Integration and Survival
Many stem cell therapies fail because transplanted cells do not survive. One of the most advanced examples of stem cell therapy is the use of adult…
Angela Panoskaltsis-Mortari, PhD, and Joseph Broomhead, MS
Manufacturing and Testing of Tissue-Engineered Pre-Aligned Muscle Fibers for Regenerative Therapies
Human skeletal muscle is challenging to create because it is composed of many thin fibers that must be precisely aligned in complex patterns. To…
Jonathan Sachs, PhD
Phenotypic Biosensors for Testing Cellular Fitness and Disease Risk using Tissue- Specific iPSC Organoids
A major challenge in regenerative medicine is the ability to predict disease risk, therapeutic outcomes and personalize treatments. The goal of this…
Michael Barry, PhD
Molecular Therapies for Alport Syndrome and Chronic Kidney Disease
Alport Syndrome (AS) is a genetic disease caused by mutations in genes that form the structural foundations of the kidney, ear, and eye causing them…
Andres Crane, PhD
Bispecific T-cell Engager for Immune Reset in Systemic Sclerosis
Scleroderma is a chronic autoimmune disease with no known cure. In this condition, B immune cells mistakenly produce antibodies that target the body’…
Douglas Brownfield, PhD
OPROTAC Degraders of C/EBPα to Promote AT2 Regeneration and Lung Repair
This project aims to test whether a new type of molecule can help the lungs heal themselves after injury. These molecules, called OPROTACs, are…
Paolo Provenzano, PhD
Physically Optimized Immune Cell Therapy for Fibrotic Disease
Fibrotic diseases, including those affecting the lungs, liver, kidneys, heart, and skin, negatively impact millions of people in the United States…
Andrew Khalil, PhD, Brenda Ogle, PhD, and Anna Kellner, PhD
Engineering Human Heart Models to Advance Minnesota-Grown Therapeutics and Prevent Radiotherapy-Induced Cardiac Degeneration
Radiotherapy is a cornerstone of modern cancer treatment, using ionizing radiation to destroy tumor cells in over half of all patients. While…
David Deyle, MD
Gene Therapy to Treat Neurofibromatosis using a Foamy Viral Vector
Neurofibromatosis type 1 (NF1) is a common genetic condition marked by features such as café-au-lait skin spots, freckling in the underarm and groin…
Bhairab Singh, PhD, John Bischof, PhD, and Brenda Ogle, PhD
Cryopreservation of Human 3D-engineered Heart Tissue (3D-EHT) for Myocardial Regenerative Therapy
3D-engineered heart tissue (3D-EHT) has emerged as a promising strategy for repairing the heart after a heart attack. Preclinical studies have…
Melanie Graham, MPH, PhD
Minnesota BRIDGE — Boosting Regenerative Medicine Innovation through Development, Growth, and Engagement
This project focuses on a major translational bottleneck: the lack of robust preclinical models. Minnesota BRIDGE will create a state-of-the-art…
David Largaespada, PhD
The Genome Engineering for Regenerative Medicine (GERM) Consortium
Addressing the critical need for quality and safety standards in gene-edited therapies, this new consortium will bring together academic and industry…