Feasibility of Reducing Inflammation and Lung Injury to Regenerate Lung Tissue Using an Extracellular Biotherapeutic Aerosol in a Model of Acute Respiratory Distress Syndrome (ARDS)

Acute respiratory distress syndrome (ARDS) is a severe form of lung injury and a common cause of respiratory failure. Effective drug therapies that address underlying mechanisms have not been realized and ARDS remains a leading cause of death in critically ill patients. Biologic therapeutics derived from mesenchymal stem cells and exosomes are currently being evaluated as a therapeutic strategy. However, their effectiveness is limited by the ability to reach the lungs. To overcome this limitation, Quench Medical is developing a minimally invasive inhaled biologic aerosol that delivers exosome-based therapeutics directly to lung tissues. This project aims to demonstrate the efficacy of this approach in reducing inflammation from ARDS and regenerating damaged lung tissue.