Inhibition of cell reprogramming by inflammatory macrophages

Reprogramming one type of cell into another has gained significant interest as a potential strategy for regenerative medicine. However, current methods are not yet efficient enough, which limits their practical use. Most research so far has focused on how cells are reprogrammed individually, without considering the effects of neighboring cells, such as immune cells, in the same environment. This phenomenon is known as the “bystander effect.” Recent studies have shown that immune cells like macrophages can enhance cell reprogramming, and this effect depends on the cell’s circadian rhythm. This project aims to build on these findings to uncover the connections between cell reprogramming, macrophages, and circadian regulation. Ultimately, this work could improve regenerative medicine approaches for treating various diseases and injuries, benefiting people in Minnesota and beyond.