Multiplex engineered gamma delta T cell-derived iPSC platform for therapeutic application

Cellular therapies using both engineered and non-engineered immune cells have been applied to treat cancer and infectious diseases. This project focuses on developing an off-the-shelf, allogeneic cellular therapy using gamma delta (γδ) T cells—powerful but rare immune cells—to target cancer, autoimmune conditions, and infectious diseases. The research team will genetically engineer γδ T cells derived from reprogrammed human stem cells and test their function in cell culture assays. The long-term goal is to create a bank of these engineered cells with specialized functions to combat a variety of diseases.