Reactivating Netrin1/DCC Signaling to Promote Optic Nerve Regeneration

Vision impairment that results from optic nerve damage, such as from glaucoma, poses a significant challenge to public health. To date, there are no effective therapeutics to block or reverse optic nerve degeneration, leading to irreversible vision impairment, including blindness. This project aims to identify molecular mechanisms that could be targeted therapeutically to promote regeneration of the optic nerve.