Generating cholangiocytes to study and treat liver disorders
Cholangiocytes are the specialized cells that line the bile ducts within the liver. These cells are the target of a group of liver diseases, known as cholangiopathies, which currently can’t be treated without completing a liver transplant. Liver transplants are not widely available, and even when a match is found, the surgery is risky, and the patient's body may refuse the transplanted liver.