Use of Human Lung Exosomes to Prevent Ischemia/Reperfusion Injury in Lung Transplantation

This study aims to mitigate ischemia reperfusion injury (IRI), a major cause of primary graft dysfunction in lung transplants, by using an FDA-approved lung spheroid cell exosome (LSC-Exo) therapy. Preliminary studies show that LSC-Exo improves lung function and reduces IRI. Researchers will test LSC-Exo in a lung transplant model and in human donor lungs rejected for transplant. Their goal is to enhance lung transplant outcomes, increase the number of usable donor lungs, and improve patient survival and quality of life. Successful completion of this study will pave the way for clinical trials.