Bioengineering of Mesenchymal Stromal Cells for Regenerative Medicine

Mesenchymal stromal cells (MSCs) have intrinsic immunosuppressive and regenerative properties. We seek to engineer MSCs with artificial receptors to enhance these properties and improve therapeutic efficacy for the treatment of autoimmune disease. We will use mouse models of colitis to test the benefits of these engineered MSCs over unmodified MSCs. We aim to broaden treatment options for patients living with ulcerative colitis, Crohn's disease, and other autoimmune disorders.