Development of technolgy for the large-scale production of a novel dendritic cell vaccine for the treatment of glioblastoma
Grant Project Details:
We plan to isolate and expand glioblastoma (GBM) cells from commercially available fresh tumor tissue. These cells will be used to create tumor antigen libraries that, in a clinical setting, would be able to prime GBM patients' dendritic cells to present Tumor Associated Antigens (TAAs) to immune cells for a targeted therapy. The cell lines created during this project will only be used for research purposes, as a proof of concept that the technology can be adapted to production at large scale.