Humanized vasculature in gene edited animals

The long term goal of our research proposal is to generate a human organ (vasculature) in pigs, which will serve as an unlimited source of vessels for clinical research of human vasculature in a large animal model and serve as a potential vascular source for patients with chronic cardiovascular disease. To ultimately achieve this overall goal, this application will provide foundational studies to engineer chimeric pigs to rescue a genetically modified pig that lacks vasculature.We believe that the proposed studies will revolutionize cardiovascular care and ultimately lead to a cure for cardiovascular disease and have a tremendous impact on our society.