Identifying and targeting antigen specific T cells in diabetes to preserve beta cells
Grant Project Details:
Awardee:
Brian Fife, PhD
Timeframe:
2016-2018
Location:
University of Minnesota | Minneapolis, MN
Amount:
$250,000
Status:
Complete
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Grant Location
University of Minnesota
2101 6th St SE
Minneapolis, MN 55455
Grant Description
The primary goals of this project are to restore immune homeostasis that allows islet beta cell survival and regeneration as a cure for Type 1 diabetes (T1D). We have generated novel tetramer reagents and will use them to track and phenotype diabetes relevant T cells in T1D patients. These reagents will also be coupled to toxins and used to selectively kill self-reactive T cells and allow pancreatic islet beta cells to survive and regenerate.
Grant Awardee Biography
Dr. Brian Fife is an Assistant Professor of medicine in the Division of Rheumatic and Autoimmune Disorders of the Department of Medicine at the University of Minnesota.