Translational Strategies for Cardiovascular Repair and Regeneration
Grant Project Details:
Cardiovascular disease in the number one cause of death worldwide and it is the most common cause of death in the United States. This grant proposal is focused on novel regulators of cardiomyocyte proliferation and provides a platform for translational medicine in large animals during cardiac repair and regeneration. The aim of this grant proposal is to decipher the pathways and the mechanisms that govern adult cardiomyocyte proliferation and identify potential therapeutic targets to promote heart regeneration in vivo. This will serve as an important platform for the mechanistic as well as translational understanding of cardiac regeneration and will have a significant impact for the field of regenerative medicine. The studies in the injured pig heart are intended as a preclinical, translational initiative. Our published and preliminary data uses established state-of-the-art technologies to provide a platform for our proposed studies. We believe that the proposed studies will revolutionize cardiovascular care and ultimately lead to a cure for cardiovascular disease and have a tremendous impact on our society.
Research Focus: Cardiovascular disease