Regenerating Lung Homeostasis to Treat Chronic Obstructive Pulmonary Disease in Humanized Mice
We have generated a novel expeditious model of cigarette smoke-induced COPD in mice that expresses human immune genes and mimics human immune response. Our main goal is to treat emphysema in mice with a novel human oral bacterium (isolated in our laboratory), which is known to be lacking in COPD patients. We believe that this treatment will improvement lung function altered by smoking. Since the bacteria are present in healthy individuals, if proven, this can be used for treating COPD.
Translational Strategies for Cardiovascular Repair and Regeneration
Investigation of Serotonergic Signaling Mechanisms that Promote Regeneration Following Spinal Cord Injury
Targeting Adenosine A2A Receptor as a Novel Regenerative Therapy in Improving Chemobrain
Killing Cancer Cells by Activating the Cellular Intrinsic Nuclear Loss Program
A major problem in leukemia treatment is the rise of drug-resistant mutations in the genome of cancer cells, which makes many well-designed cancer drugs ineffective over time. To solve this critical issue, here, we will develop a novel method of killing leukemia cells by inducing them to expel their nuclei.
Research Focus: Leukemias
Saphenous Vein Extracellular Matrix Scaffolds for Use in Coronary Artery Bypass
Protein Removal and Purification of Platelet Rich Plasma (PRP2)
Patient-derived Mesenchymal Stromal Cell Therapy in Diabetic Kidney Disease: A Phase I Study
Innovators of the Future: Community Based Science Program
Sites: Multiple
Bois Forte Band of Chippewa - Nett Lake Elementary School
Grand Portage Band of Lake Superior Chippewa - Oshki Ogimaag Community School